Completely revised and updated, the Third Edition of this classic text reflects the latest advances in research on orthopaedic biomechanics and the successful applications of biomechanical principles in fracture fixation, prosthetic implant design, and hip and knee arthroplasty. For this Third Edition, Dr. Mow is joined by new co-editor Rik Huiskes, PhD, an Editor-in-Chief of the Journal of Biomechanics and an internationally renowned authority in the field. New chapters cover biomaterials, biomechanical principles of tissue engineering, and computer-aided and robotic surgery. View More...
Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action.- Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner- Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules- Features interactive... View More...
Data availability is surpassing existing paradigms for governing, managing, analyzing, and interpreting health data. Big Data and Health Analytics provides frameworks, use cases, and examples that illustrate the role of big data and analytics in modern health care, including how public health information can inform health delivery. Written for health care professionals and executives, this is not a technical book on the use of statistics and machine-learning algorithms for extracting knowledge out of data, nor a book on the intricacies of database design. Instead, this book presents the curren... View More...
In recent years, developmental neurobiologists have made significant progress toward understanding the processes that determine normal organization and function of the central nervous system. Although this research provides the necessary basis for examining the factors that contribute to the age-dependent expression of seizures, there has been surprisingly little communication between developmental neurobiologists and the clinicians who deal with pediatric epilepsy patients. An understanding of normal and pathological functions in the immature central nervous system requires a special apprecia... View More...
This new edition of the benchmark text on clinical pediatric endocrinology still remains at the forefront of world clinical opinion. Furthermore, the style, which has been the hallmark of the book for the last 20 years, has been maintained for this Fifth Edition. New features of this Fifth Edition include: Special new chapters cover the fetal origins of adult disease and the endocrine consequences and management of critical illness Now opens with a basic science section summarizing the mechanisms of hormone action, genomics, proteomics and the application of molecular biology to clinical... View More...
Pacing and defibrillation have become the leading therapeutic treatments of heart rhythm disorders, including bradycardia and tachycardia. The success of these therapies is largely due to centuries of scientific inquiry into the fundamental mechanisms of bioelectric phenomena in the heart. History of successful development of bioelectric therapies includes development of experimental and theoretical methodologies, novel bioengineering approaches, and state-of-the-art clinical implantable device therapies. The purpose of this book is to present a uniform thematic collection of reviews written... View More...
Clinical Trial Optimization Using R explores a unified and broadly applicable framework for optimizing decision making and strategy selection in clinical development, through a series of examples and case studies. It provides the clinical researcher with a powerful evaluation paradigm, as well as supportive R tools, to evaluate and select among simultaneous competing designs or analysis options. It is applicable broadly to statisticians and other quantitative clinical trialists, who have an interest in optimizing clinical trials, clinical trial programs, or associated analytics and decision ma... View More...
This is the first comprehensive review of mRNA stability and its implications for regulation of gene expression. Written by experts in the field, Control of Messenger RNA Stability serves both as a reference for specialists in regulation of mRNA stability and as a general introduction for a broader community of scientists. View More...
The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. W... View More...
Leading experts explain infectious disease in an illustrated companion to the acclaimed American Museum of Natural History's exhibit. Epidemic explores the world of infectious disease with essays by Nobel Prize-winning experts, profiles of scientists and researchers, and case studies. Written for the general reader, Epidemic offers a clear understanding of the threat of infectious diseases, from the flu and mad cow disease to HIV and tuberculosis. Leaders of organizations such as the Centers for Disease Control cover topics from controlling outbreaks and the emergence of new diseases to the ... View More...
Health Informatics (HI) focuses on the application of information technology (IT) to the field of medicine to improve individual and population healthcare delivery, education and research. This extensively updated fifth edition reflects the current knowledge in Health Informatics and provides learning objectives, key points, case studies and references. Topics include: HI Overview; Healthcare Data, Information, and Knowledge; Electronic Health Records, Practice Management Systems; Health Information Exchange; Data Standards; Architectures of Information Systems;Health Information Privacy and S... View More...
This book provides a unique consideration of the role of an increasingly common disease. By drawing together a wide range of recent contemporary thought and research, sharing a feminist perspective which asserts the presence of women with the disease, the many meanings of breast cancer are revealed. Individual chapters consider issues of risk, environmental justice, political activism in California, women's construction of breast cancer knowledge, popular media representations of the disease, and published autobiographical narratives.
